中文名 | 西他列汀 |
英文名 | Sitagliptin |
别名 | 西格列汀 西他列汀 西他列汀游离碱 西他(格)列汀杂质 西他(格)列汀杂质A 西他列汀碱(西他列汀中间体) SITAGLIPTIN 西他列汀 (3R)-3-氨基-1-[3-(三氟甲基)-5,6,7,8-四氢-1,2,4-三唑并[4,3-a]吡嗪-7-基]-4-(2,4,5-三氟苯基)丁-1-酮 (3R)-3-氨基-1-(3-(三氟甲基)-5,6,7,8-四氢-1,2,4-三唑并(4,3-a)吡嗪-7-基)-4-(2,4,5-三氟苯基)丁-1-酮 (R)-3-氨基-1-(3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基)-4- (2,4,5-三氟苯基)丁-1-(西格列汀杂质) |
英文别名 | Sitagliptin Sitagliptin-D4 Sitagliptin base Sitagliptin-D4 HCL Sitagliptin Intermediate (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one (3S)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine 1,2,4-Triazolo(4,3-a)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)- (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one Sitagliptin (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one (3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one |
CAS | 486460-32-6 790712-60-6 |
EINECS | 690-730-1 |
化学式 | C16H15F6N5O |
分子量 | 407.31 |
InChI | InChI=1/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m0/s1 |
密度 | 1.61±0.1 g/cm3(Predicted) |
熔点 | 114.1-115.7 °C |
沸点 | 529.9±60.0 °C(Predicted) |
闪点 | 274.277°C |
蒸汽压 | 0mmHg at 25°C |
折射率 | 1.59 |
酸度系数 | 7.20±0.10(Predicted) |
存储条件 | 2-8℃ |
外观 | 白色固体粉末 |
MDL号 | MFCD09838015 |
参考资料 展开查看 | 1. Guo, Xiumei, et al. "Fabrication of a water-soluble near-infrared fluorescent probe for selective detection and imaging of dipeptidyl peptidase IV in biological systems." Journal of Materials Chemistry B 8.4 (2020): 767-775.https://doi.org/10.1039/C9TB0230 2. Tao Liu, Jing Ning, Bo Wang, Bin Dong, Song Li, Xiangge Tian, Zhenlong Yu, Yulin Peng, Chao Wang, Xinyu Zhao, Xiaokui Huo, Chengpeng Sun, Jingnan Cui, Lei Feng, and Xiaochi MaAnalytical Chemistry 2018 90 (6), 3965-3973DOI: 10.1021/acs.analchem.7b04957 3. [IF=6.986] Tao Liu et al."Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals."Anal Chem. 2018;90(6):3965–3973 4. [IF=6.331] Xiumei Guo et al."Fabrication of a water-soluble near-infrared fluorescent probe for selective detection and imaging of dipeptidyl peptidase IV in biological systems."J Mater Chem B. 2020 Jan;8(4):767-775 5. [IF=5.279] Lingyan Dai et al."Analysis of the Structure and Activity of Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Oligopeptides from Sorghum Kafirin."J Agr Food Chem. 2022;70(6):2010–2017 |
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